Richard O Williams Selected Research

Enzymes

1/2023	Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
1/2022	Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?
1/2014	Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis.
1/2013	Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis.

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Richard O Williams Research Topics

Disease

34	Rheumatoid Arthritis 01/2023 - 01/2004
28	Arthritis (Polyarthritis) 01/2022 - 03/2003
28	Experimental Arthritis 01/2022 - 01/2002
20	Inflammation (Inflammations) 03/2024 - 12/2004
7	Autoimmune Diseases (Autoimmune Disease) 03/2024 - 01/2005
7	Necrosis 08/2011 - 12/2004
6	Pain (Aches) 12/2023 - 10/2008
4	Neoplasms (Cancer) 03/2024 - 01/2022
4	Osteoarthritis 01/2022 - 10/2008
4	Disease Progression 01/2019 - 01/2014
2	Infections 05/2023 - 01/2018
2	Ankylosing Spondylitis 01/2021 - 08/2007
2	Synovitis 12/2016 - 01/2007
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2015 - 08/2007
2	Multiple Sclerosis 09/2012 - 10/2008
1	Carcinogenesis 01/2022
1	Hypersensitivity (Allergy) 01/2022
1	Immune System Diseases (Immune Disorders) 01/2022
1	Autoimmune Diseases of the Nervous System 01/2022
1	Obesity 09/2021
1	Cardiomyopathies (Cardiomyopathy) 01/2021
1	Myocarditis (Carditis) 01/2021
1	Huntington Disease (Huntington's Disease) 01/2020
1	Osteoporosis 01/2020
1	Trypanosomiasis 01/2020
1	Cerebral Malaria 01/2020
1	Stroke (Strokes) 01/2019
1	Asthma (Bronchial Asthma) 01/2019
1	Atherosclerotic Plaque (Atheroma) 10/2015
1	Atherosclerosis 10/2015

Drug/Important Bio-Agent (IBA)

15	CytokinesIBA 01/2022 - 03/2003
13	Collagen Type II (Type II Collagen)IBA 01/2019 - 03/2003
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2016 - 12/2004
8	KynurenineIBA 05/2023 - 05/2009
5	Proteins (Proteins, Gene)FDA Link 12/2023 - 04/2008
5	Tryptophan (L-Tryptophan)FDA Link 05/2023 - 05/2009
5	Interleukin-17 (Interleukin 17)IBA 01/2019 - 10/2008
4	EnzymesIBA 01/2023 - 01/2013
4	anthranilic acid (anthranilate)IBA 01/2020 - 01/2013
4	Etanercept (Enbrel)FDA Link 02/2016 - 01/2007
3	CollagenIBA 01/2022 - 08/2010
3	Interleukin-10 (Interleukin 10)IBA 01/2020 - 01/2007
3	ChemokinesIBA 01/2019 - 10/2015
3	Monoclonal AntibodiesIBA 01/2010 - 04/2008
2	Type II Tumor Necrosis Factor ReceptorsIBA 03/2024 - 10/2019
2	Type I Tumor Necrosis Factor ReceptorsIBA 03/2024 - 08/2011
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2020
2	AntigensIBA 01/2022 - 01/2020
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021 - 08/2010
2	AcidsIBA 01/2020 - 01/2020
2	Phosphodiesterase 4 InhibitorsIBA 01/2019 - 01/2010
2	Therapeutic UsesIBA 01/2016 - 01/2002
2	Methotrexate (Mexate)FDA LinkGeneric 05/2015 - 10/2010
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 10/2014 - 08/2011
2	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 09/2014 - 05/2009
2	nimesulide (Aulin)IBA 01/2014 - 10/2010
2	Peroxidase (Myeloperoxidase)IBA 01/2014 - 08/2011
2	Antisense OligonucleotidesIBA 04/2009 - 10/2008
1	Kynurenic Acid (Kynurenate)IBA 12/2023
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 12/2023
1	Amino Acids FDA Link 01/2023
1	invariant chain (Ii-Key)IBA 01/2022
1	carfilzomibIBA 01/2022
1	EmulsionsIBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	Staphylococcal Protein A (Protein A)IBA 01/2022
1	VaccinesIBA 01/2022
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2022
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2022
1	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2022
1	SubtilisinIBA 01/2022
1	Virulence Factors (Pathogenicity Factors)IBA 01/2022
1	Serine Proteases (Serine Protease)IBA 01/2022
1	Decitabine FDA Link 11/2021
1	Nucleoside Transport Proteins (Nucleoside Transporter)IBA 11/2021
1	Calcium Gluconate (CBG)IBA 09/2021
1	interleukin 20 (IL-20)IBA 01/2021
1	idelalisibIBA 01/2021
1	ibrutinibIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	SteroidsIBA 01/2020
1	ibudilastIBA 01/2019
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 01/2019
1	Immunoglobulin Fc FragmentsIBA 01/2018
1	rho GTPase-activating proteinIBA 01/2018
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/2017
1	Matrix Metalloproteinases (MMPs)IBA 02/2016
1	DX-2400IBA 02/2016
1	Peptide Hydrolases (Proteases)FDA Link 02/2016
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 02/2016
1	N- alpha- benzoyl- N5- (2- chloro- 1- iminoethyl)- L- ornithine amideIBA 01/2016
1	arginine deiminaseIBA 01/2016
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2016
1	Interleukin-4 (Interleukin 4)IBA 01/2016
1	N-(3',4'-dimethoxycinnamonyl)anthranilic acidIBA 10/2015
1	LipidsIBA 10/2015

Therapy/Procedure

22	Therapeutics 01/2022 - 02/2004
2	Analgesia 08/2015 - 01/2014
1	Aftercare (After-Treatment) 01/2019